10 Best Calming Products For Cats 2025 in the United States

The TherapetMD Cat Calming Diffuser is a plug-in pheromone diffuser designed to reduce anxiety and stress in cats, especially in multi-cat households. It uses a natural, vet-recommended dual-pheromone formula that mimics facial and maternal cat pheromones, helping to significantly cut down behaviors like urine spraying and scratching. One of its strengths is the 700 sq ft coverage area, making it suitable for larger rooms or shared spaces.

The diffuser works continuously once plugged in, with each refill lasting about 30 days, so it’s convenient and requires minimal effort from owners. It’s fragrance-free and safe for cats, humans, and other pets, which is important for households with multiple animals or sensitive individuals. Many users report noticeable improvements in reducing hiding, fear, and tension between cats, making it helpful during stressful events like vet visits or introducing new pets. It may take a few days to see the calming effects, and the low-glow indicator light might be hard to notice in bright settings, though this doesn’t affect the diffuser’s function.

Some cats may respond differently depending on their individual preferences, so results can vary. This diffuser provides a gentle, chemical-free way to create a calmer environment for anxious or stressed cats without hassle, although patience is needed to observe the full benefits.

The Vetoquinol Zylkene Calming Supplement is designed to help small dogs and cats manage stress from situations like travel, vet visits, or loud noises. Its main calming ingredient, alpha-casozepine, comes from a milk protein, making it a natural option that avoids drowsiness or harsh side effects commonly seen in other calming products.

This supplement is lactose-free and gentle on sensitive stomachs, which is beneficial for cats with digestive sensitivities. The package contains capsules that you open and sprinkle over your pet’s food, making it straightforward to use daily. This daily routine can support behavioral issues and help your cat stay calm during stressful events.

With a solid positive rating from many users, Zylkene offers a safe, gentle, and easy-to-administer way to support your cat’s relaxation. Pet owners should monitor their cat’s response and ensure proper dosing.

The Comfort Zone Multi Cat Calming Diffuser Refills are a drug-free, fragrance-free solution designed to reduce tension and aggressive behaviors in multi-cat households. This product uses calming pheromones to help manage issues like swatting, scratching, and fighting. The refills are compatible only with Comfort Zone diffusers, which are reusable for up to 12 months. Each refill lasts about 30 days, providing up to six months of continuous calming support with the included six-pack value set.

The diffusers effectively cover up to 400 square feet, making them suitable for larger rooms where your cats spend most of their time. Safety is a key aspect, with the product meeting Intertek electrical safety and certified to UL standards, and an automatic shut-off feature to prevent overheating. While the diffuser is easy to use, it requires proper placement—upright and not obstructed by furniture for optimal performance.

Users should note that the product might not work with other brands’ diffusers and must be replaced monthly for consistent effectiveness. Additionally, the lack of fragrance might be a plus for some, but it could also mean it's less noticeable when it's working. This calming solution may be particularly beneficial for households with more than one cat experiencing behavioral issues.